[pubmed] The Clinical Features of LRP4/Agrin Antibody Positive Myasthenia Gravis: A Multi-center Study

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Rivner MH, et al. Muscle Nerve 2020.

ABSTRACT

The Clinical Features of LRP4/Agrin Antibody-Positive Myasthenia Gravis: A Multi-center Study OBJECTIVE: To study prevalence and clinical characteristics of LRP4/Agrin antibody-positive double seronegative MG (DNMG).

METHODS: DNMG patients at 16 US sites were tested for LRP4 and Agrin antibodies and clinical data was collected.

RESULTS: Of 181 DNMG patients, 14.9% (27) were positive for either LRP4 or Agrin antibodies. Twenty-three DNMG patients (12.7%) were positive for both antibodies. More antibody-positive patients presented with generalized symptoms (69%) compared to antibody-negative patients (43%) (p

Source: https://pubmed.ncbi.nlm.nih.gov/3248383 ... 51&v=2.8.0