[pubmed] Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of pa

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[pubmed] Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of pa

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BMJ Open. 2020 Sep 18;10(9):e037909. doi: 10.1136/bmjopen-2020-037909.

ABSTRACT

OBJECTIVES: To approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families.

DESIGN: Retrospective cohort study.

SETTING: Clinics across North America.

PARTICIPANTS: The study included 1032 patients diagnosed with acetylcholine receptor antibody (AChR)-positive myasthenia gravis.

METHODS: Phenotype information of 1032 patients diagnosed with AChR-positive myasthenia gravis was obtained from clinics at 14 centres across North America between January 2010 and January 2011. A critical review of the epidemiological literature on the familial rate of myasthenia gravis was also performed.

RESULTS: Among 1032 patients, 58 (5.6%) reported a family history of myasthenia gravis. A history of autoimmune diseases was present in 26.6% of patients and in 28.4% of their family members.

DISCUSSION: The familial rate of myasthenia gravis was higher than would be expected for a sporadic disease. Furthermore, a high proportion of patients had a personal or family history of autoimmune disease. Taken together, these findings suggest a genetic contribution to the pathogenesis of myasthenia gravis.

PMID:32948566 | DOI:10.1136/bmjopen-2020-037909


Source: https://pubmed.ncbi.nlm.nih.gov/3294856 ... 7&v=2.11.5
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