[pubmed] SARS-CoV-2 (COVID-19) in Patients with some Degree of Immunosuppression

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Reumatol Clin. 2020 Sep 11:S1699-258X(20)30201-1. doi: 10.1016/j.reuma.2020.08.004. Online ahead of print.

ABSTRACT

BACKGROUND: It is not clear whether patients with some degree of immunosuppression have worse outcomes in SARS-CoV-2 infection, compared to healthy people.

OBJECTIVE: To carry out a narrative review of the information available on infection by SARS-CoV-2 in immunosuppressed patients, especially patients with cancer, transplanted, neurological diseases, primary and secondary immunodeficiencies.

RESULTS: Patients with cancer and recent cancer treatment (chemotherapy or surgery) and SARS-CoV-2 infection have a higher risk of worse outcomes. In transplant patients (renal, cardiac and hepatic), with neurological pathologies (multiple sclerosis [MS], neuromyelitis optica [NMODS], myasthenia gravis [MG]), primary immunodeficiencies and infection with human immunodeficiency virus (HIV) in association with immunosuppressants, studies have shown no tendency for worse outcomes.

CONCLUSION: Given the little evidence we have so far, the behaviour of SARS-CoV-2 infection in immunosuppressed patients is unclear, but current studies have not shown worse outcomes, except for patients with cancer.

PMID:32994151 | DOI:10.1016/j.reuma.2020.08.004


Source: https://pubmed.ncbi.nlm.nih.gov/3299415 ... 6&v=2.12.1