[pubmed] Determinants of Suboptimal Outcome Following Thymectomy in Myasthenia Gravis

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[pubmed] Determinants of Suboptimal Outcome Following Thymectomy in Myasthenia Gravis

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Neurol India. 2021 Mar-Apr;69(2):419-425. doi: 10.4103/0028-3886.314565.

ABSTRACT

BACKGROUND: Response to thymectomy in myasthenia gravis (MG) is influenced by various patient-, disease-, and therapy-related factors.

METHODS: Retrospective analysis of 128 patients with MG who underwent maximal thymectomy over 15 years was done to identify the determinants of suboptimal clinical outcome.

RESULTS: Among the 128 patients, 62 (48.4%) were females with a mean age of 38.97 (12.29) years. Thymomatous MG occurred in 66 (51.6%). Overall improvement from preoperative status was noted in 88 (68.8%) patients after mean follow-up of 51.68 (33.21) months. The presence of thymoma was the major predictor of suboptimal clinical outcome (P = 0.001), whereas age, gender, preoperative disease severity, and seropositive status did not attain significance. Patients with better outcome had received higher steroid dose preoperatively (P = 0.035).

CONCLUSIONS: Suboptimal response after thymectomy occurred in one-third of MG patients, more commonly with thymomatous MG. Relationship of preoperative steroid therapy to remission merits evaluation.

PMID:33904466 | DOI:10.4103/0028-3886.314565


Source: https://pubmed.ncbi.nlm.nih.gov/3390446 ... 1&v=2.14.4
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