[pubmed] Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery

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Ann Thorac Cardiovasc Surg. 2021 Jul 16. doi: 10.5761/atcs.cr.21-00052. Online ahead of print.

ABSTRACT

INTRODUCTION: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder. Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately 5% of all SPS cases. We present a rare case of thymoma accompanied by SPS successfully treated using surgery.

PRESENTATION OF CASE: A 26-year-old woman presented with lower limbs convulsions and gait disturbance and complained of leg pain. Cerebrospinal fluid and blood test results showed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computed tomography showed anterior mediastinal tumor suggestive of a thymoma. She underwent extended thymectomy, and her symptoms gradually improved after surgery. No evidence of recurrent thymoma and SPS has been observed over 44 months.

CONCLUSION: Surgical treatment would be effective for patients with SPS and thymoma.

PMID:34275989 | DOI:10.5761/atcs.cr.21-00052


Source: https://pubmed.ncbi.nlm.nih.gov/3427598 ... 5&v=2.14.5