[pubmed] To Be or Not To Be Vaccinated: That Is a Question in Myasthenia Gravis
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Auteur du sujet - Ami(e) de Diamant
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[pubmed] To Be or Not To Be Vaccinated: That Is a Question in Myasthenia Gravis
Front Immunol. 2021 Sep 17;12:733418. doi: 10.3389/fimmu.2021.733418. eCollection 2021.
ABSTRACT
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and abnormal fatigability due to the antibodies against postsynaptic receptors. Despite the individual discrepancy, patients with MG share common muscle weakness, autoimmune dysfunction, and immunosuppressive treatment, which predispose them to infections that can trigger or exacerbate MG. Vaccination, as a mainstay of prophylaxis, is a major management strategy. However, the past years have seen growth in vaccine hesitancy, owing to safety and efficacy concerns. Ironically, vaccines, serving as an essential and effective means of defense, may induce similar immune cross-reactivity to what they are meant to prevent. Herein, we outline the progress in vaccination, review the current status, and postulate the clinical association among MG, vaccination, and immunosuppression. We also address safety and efficacy concerns of vaccination in MG, in relation to COVID-19. Since only a handful of studies have reported vaccination in individuals with MG, we further review the current clinical studies and guidelines in rheumatic diseases. Overall, our reviews offer a reference to guide future vaccine clinical decision-making and improve the management of MG patients.
PMID:34603311 | PMC:PMC8485039 | DOI:10.3389/fimmu.2021.733418
Source: https://pubmed.ncbi.nlm.nih.gov/3460331 ... 8&v=2.15.0
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Pour obtenir la traduction en français,
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Pour les donateurs, si cet article vous intéresse, nous pouvons faire l’acquisition d'un tiré-à-part.
Merci d'en faire la demande sur association.amis-modo@myasthenie.com
Bonne lecture...