[pubmed] Fatigue in patients with myasthenia gravis. A systematic review of the literature
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Auteur du sujet - Ami(e) de Diamant
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[pubmed] Fatigue in patients with myasthenia gravis. A systematic review of the literature
Neuromuscul Disord. 2020 Jul 1:S0960-8966(20)30160-7. doi: 10.1016/j.nmd.2020.06.010. Online ahead of print.
ABSTRACT
Myasthenia Gravis (MG) is a chronic autoimmune disease affecting the neuromuscular junction. Although a hallmark of MG is muscle fatigability due to dysfunction of the neuromuscular junction (peripheral fatigue), a large number of MG patients also report symptoms of central fatigue, defined as an experienced lack of energy, physically and/or mentally. We systematically reviewed the literature on all aspects of central fatigue in MG. Results were categorized in 5 domains: prevalence, diagnosis, pathophysiology, treatment or impact. The prevalence of patient-reported fatigue varies between 42 and 82%, which is significantly higher than in control subjects. Fatigue severity is usually assessed with standardized questionnaires, but the choice of questionnaire varies widely between studies. The pathophysiology of fatigue is unknown, but it is strongly associated with depressive symptoms, female gender and disease severity. Fatigue is also highly prevalent in ocular MG and patients in remission, suggesting a multifactorial origin. Fatigued MG patients have a lower quality of life. Pharmacological treatment of MG is associated with improvement of fatigue and promising results have been found with physical and psychological training programs. Fatigue is a highly prevalent symptom of MG with a severe negative impact on quality of life. Physicians treating patients with MG should be aware of this symptom, as it may be treatable with physical or psychological training programs.
PMID:32718868 | DOI:10.1016/j.nmd.2020.06.010
Source: https://pubmed.ncbi.nlm.nih.gov/3271886 ... 3&v=2.11.4
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Pour obtenir la traduction en français,
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Pour les donateurs, si cet article vous intéresse, nous pouvons faire l’acquisition d'un tiré-à-part.
Merci d'en faire la demande sur association.amis-modo@myasthenie.com
Bonne lecture...