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Factors predicting remission in thymectomized patients with acetylcholine receptor antibody-positive myasthenia gravis.
Kim H1, Lim YM1, Lee EJ1, Oh YJ1, Kim KK1.
Muscle Nerve. 2018 Jul 18. doi: 10.1002/mus.26300. [Epub ahead of print]
Abstract
- INTRODUCTION:
Although thymectomy is an important therapeutic option for myasthenia gravis (MG), factors predicting remission after thymectomy are not well known.
- METHODS:
We retrospectively reviewed acetylcholine receptor antibody (AChR-Ab)-positive MG patients who had undergone thymectomy. Prognostic factors predicting remission were investigated. Changes in AChR-Ab titer before and after thymectomy were also evaluated.
- RESULTS:
Among the 179 patients, 52.5% achieved complete stable or pharmacologic remission. Nonthymomatous pathology and mild preoperative status were favorable predictors of remission. The decrease in AChR-Ab titer after thymectomy was significant in nonthymomatous MG, but not in thymomatous MG.
- DISCUSSION:
Nonthymomatous pathology and mild preoperative status are prognostic factors that may predict remission after thymectomy. The decrease in AChR-Ab titer after thymectomy was significant in nonthymomatous MG but not in thymomatous MG, suggesting that the pathogenic role of the thymus differs according to pathology.
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