Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/30074608
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Efficacy and Safety of Low-to-Moderate Dose Oral Corticosteroid Treatment in Ocular Myasthenia Gravis.
Lee YG, Kim US.
J Pediatr Ophthalmol Strabismus. 2018 Jul 27:1-4. doi: 10.3928/01913913-20180620-01. [Epub ahead of print]
Abstract
- PURPOSE:
To evaluate the response to corticosteroid therapy as a primary treatment for ocular myasthenia gravis.
- METHODS:
Patients diagnosed as having ocular myasthenia gravis by an acetylcholine receptor binding antibody test between January 2011 and September 2015 were included in the study and started receiving treatment with a corticosteroid. Patients with a blowout fracture, hyperthyroidism, diabetes mellitus, hypertension, cardiovascular disease, or history of strabismus surgery were excluded. Disappearance of diplopia and ptosis were considered a response to treatment.
- RESULTS:
Methylprednisolone therapy was administered to 29 patients (19 men and 10 women; average age: 49 ± 16.5 years) as an initial treatment. A total of 6 patients were lost to follow-up. Twenty-three of 29 patients (82.6%) were regarded as having presented a response to treatment. The average treatment duration was 3 weeks for patients responding to primary treatment. Eight patients complained of adverse effects from steroid therapy such as heartburn, insomnia, weight gain, and myalgia.
- CONCLUSIONS:
A corticosteroid could be considered as an initial treatment for patients diagnosed as having ocular myasthenia gravis by an acetylcholine receptor binding antibody test.
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