Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/30181833
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Un diagnostic de myasthénie d'apparition tardive, masqué par des antibiotiques topiques.
Hussain N 1 , Hussain F 2 , Haque D 3 , Chittivelu S 4 .
J Community Hosp Intern Med Perspect. 2018 22 juin 8 (4): 230-232. doi: 10.1080 / 20009666.2018.1487245. eCollection 2018.
Abstract
Myasthenia Gravis (MG) is a disorder of the neuromuscular junction (NMJ) that manifests as fluctuating fatiguable weakness of the muscles.
There are many factors that can exacerbate myasthenia symptoms including a variety medications and drugs, systemic illness, and pregnancy. A number of medications have been implicated in exacerbating MG symptoms, including aminoglycosides.
We present a case of an elderly female with newly diagnosed MG following the use of tobramycin eye drops for 3 days. There have been limited reports in the literature of topical medications that exacerbate MG symptoms.
Clinicians prescribing tobramycin eye drops (or other associated medications) should have a high index of suspicion of MG as early discontinuation and therapy will limit long-term morbidity and mortality in these patients.
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