Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/30278997
Traduction disponible directement en cliquant en bas à droite de ce message sur l'expression Traduire en
Programmed cell death ligand 1 expression is upregulated in the skeletal muscle of patients with myasthenia gravis.
Iwasa K1, Yoshikawa H2, Furukawa Y3, Yamada M4.
J Neuroimmunol. 2018 Sep 27. pii: S0165-5728(18)30353-9. doi: 10.1016/j.jneuroim.2018.09.012.
We investigated the expression patterns of programmed cell death-ligand 1 (PD-L1) in the skeletal muscle of 15 patients with myasthenia gravis (MG).
In 11 of the patients, immunohistochemistry confirmed the localization of PD-L1 in the muscle cell membrane with cytoplasmic integrity.
PD-L1 mRNA expression levels were higher in the muscles of MG patients as compared to those of non-myogenic patients (p < .05).
Moreover, a unimodal relationship between PD-L1 mRNA levels and quantitative MG scores for disease severity was identified by a generalized additive model, indicating reciprocal effects.
Together, these results suggest that MG symptoms might influence PD-L1 expression in muscle cells, and upregulated PD-L1 expression might inhibit autoimmune reactivity.