IL-37 réprime l'auto-immunité dans la myasthénie grave via le ciblage direct des cellules folliculaires Th et B.
Lu sur : https://www.ncbi.nlm.nih.gov/pubmed/32111731
[hr]
[/hr]
Traduction disponible directement en cliquant en bas a droite de ce message sur l'expression Traduire en
[hr]
[/hr]
Titre de l'article IL-37 Represses the Autoimmunity in Myasthenia Gravis via Directly Targeting Follicular Th and B Cells.
Date de l'article J Immunol. 2020 Feb 28. pii: ji1901176. doi: 10.4049/jimmunol.1901176. [Epub ahead of print]
Contenu de l'article
IL-37 is a newly identified immune-suppressive factor; however, the function, cellular sources, and mechanism of IL-37 in humoral immunity and Myasthenia gravis (MG) are still unclear.
In this study, we found IL-37 were substantially downregulated in the serum and PBMCs of MG patients compared with healthy controls.
The lower IL-37 was associated with severer disease (quantitative MG score) and higher follicular Th (Tfh)/Tfh17 and B cell numbers.
Flow cytometry analysis revealed that IL-37 was mainly produced by CD4+ T cells without overlapping with Th1, Th17, and Tfh subsets in MG patients. Regulatory IL-37+ T cell rarely expressed Foxp3 and CD25 but produced numerous IL-4.
Tfh and B cell expressed high levels of SIGIRR, the receptor of IL-37, in MG patients. Mechanically, IL-37 directly bond to SIGIRR, repressed the proliferation, cytokine production of Tfh and B cells, and the secretion of autoantibody via inhibition of STAT3 signaling in Tfh and B cells.
[hr]
[/hr]
| Message d' un membre de l'équipe technique |
| Pour les utilisateurs d'I-phone ci-dessous le lien vers Google Trad https://translate.google.fr/translate?h ... 2F32111731 |
| Message d' un membre de l'équipe technique |
| Nous utilisons des services automatiques de traduction fournis par Yandex ou Google. Soyez vigilant sur le risque de contre-sens inhérent à ce genre d'outils. |
[/hr]
Article intégral NON disponible à l'achat
[hr]
[/hr]
