Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/30071533
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High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction after Thymectomy.
Robat-Jazi B1, Hosseini M1, Shaygannejad V2, Nafissi S3, Rezaei A1, Mansourain M4, Mirmosayyeb O5, Esmaeil N1.
Neuroimmunomodulation. 2018 Aug 2:1-9. doi: 10.1159/000490855. [Epub ahead of print]
Abstract
- OBJECTIVES:
Myasthenia gravis (MG) is an autoimmune disease accompanied by a thymic pathology and in most patients thymectomy (TE) is used as the therapeutic approach. Both B and T cells play an important role in MG pathogenesis.
- METHODS:
Twelve pre- and post-TE MG patients and 12 healthy controls (HCs) were enrolled. The mean percentages of Th22 and Tc22 cells were evaluated in MG patients (before and 6 months after TE) and HCs.
- RESULTS:
The mean percentage of Tc22 cells in pre-TE patients was significantly higher than in HCs (p < 0.05), and after TE Tc22 cells significantly decreased compared to pre-TE (p < 0.05). The frequency of Th22 cells in pre-TE MG patients was not significantly different from HCs, but after TE Th22 cells were significantly decreased compared to pre-TE (p < 0.05).
- CONCLUSION:
Our findings suggest a possible role of Th22 and Tc22 in MG pathogenesis.
© 2018 S. Karger AG, Basel.
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