[Pubmed] Electrophysiologic evaluation of myasthenia gravis and its mimics: real-world experience with single-fiber elec

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Hosp Pract (1995). 2022 Sep 14. doi: 10.1080/21548331.2022.2125706. Online ahead of print.

ABSTRACT

OBJECTIVES: In centers which routinely perform single fiber electromyography (SFEMG) for suspected myasthenia gravis (MG), the additional benefit of other neurophysiologic investigations and the frequency of myasthenia mimics has not been ascertained. We aimed to illustrate the range of neurological and non-neurological myasthenia mimics referred for evaluation, and contrast features of their electrophysiologic evaluation with confirmed MG.

METHODS: We reviewed all SFEMG studies performed at our center between January 01, 2018 and December 31, 2020. Patient demographics, clinical phenotype, antibody status and final diagnosis were recorded. Electrophysiologic findings were correlated with clinical features and sensitivity analyses performed.

RESULTS: A total of 528 SFEMG studies were performed, of which 213 (41%) were abnormal. A diagnosis of MG was made in 101 individuals, including 46 with ocular MG and 35 with seronegative disease. Compared to myasthenia mimics with an abnormal SFEMG, individuals with MG had higher median jitter (mean consecutive difference 61μs vs. 42μs, p

Source: https://pubmed.ncbi.nlm.nih.gov/3610399 ... 8&v=2.17.8