[SMLE] Physiology, Neuromuscular Transmission

[RSS-Bot]

2025 Mar 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–.

ABSTRACT

The neuromuscular junction (NMJ) is responsible for the chemical transmission of electrical impulses from nerves to muscles (skeletal, smooth, or cardiac) to facilitate appropriate muscle contraction. Disorders of the NMJ, such as myasthenia gravis, Lambert-Eaton syndrome (LES), and botulism, impair neuromuscular transmission, leading to muscle weakness and paralysis. Additionally, many drugs and anesthetic agents can influence the NMJ and disrupt impulse transmission to produce their effects. A thorough understanding of the NMJ structure and the physiology of neuromuscular transmission is essential to comprehend the pathophysiology and treatment foundations of diseases affecting neuromuscular transmission.

PMID:31082177 | Bookshelf:NBK541133


Source: https://pubmed.ncbi.nlm.nih.gov/3108217 ... t9+e462414