[pubmed] Changes in serum complements and their regulators in generalised myasthenia gravis
Posté : 05 sept. 2020 12:00
Eur J Neurol. 2020 Sep 5. doi: 10.1111/ene.14500. Online ahead of print.
ABSTRACT
OBJECTIVE: To investigate changes in serum complements and their regulators in the pathogenesis of myasthenia gravis (MG).
METHODS: Forty-four patients with acetylcholine receptor antibodies-positive MG, as well as 20 patients with noninflammatory neurological disorders were enrolled. Serum complements (C3, C4 and soluble C5b-9) and complement regulators (vitronectin, clusterin and properdin) were extensively analysed by ELISA and the associations with clinical profiles of MG were examined.
RESULTS: Serum C3, C4 and clusterin levels were not significantly different between patients with MG and controls. The patients with MG showed higher soluble C5b-9 (p = 0.09) and vitronectin (p = 0.001) levels than the controls; moreover, vitronectin levels decreased after treatment (p = 0.09). Serum properdin (p = 0.03) levels were lower in the patients with MG than in the controls, and negatively correlated with the MG activities of daily living score (rs = -0.26, p = 0.09) and with the presence of bulbar palsy (p = 0.04).
CONCLUSION: Our results show that activation of complements and an altered complement network could contribute to the inflammatory pathogenesis of MG.
PMID:32889770 | DOI:10.1111/ene.14500
Source: https://pubmed.ncbi.nlm.nih.gov/3288977 ... 2&v=2.11.5