[pubmed] Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis
Posté : 07 mai 2021 12:00
J Neuroimmunol. 2021 Apr 30;356:577588. doi: 10.1016/j.jneuroim.2021.577588. Online ahead of print.
ABSTRACT
Autoantibodies against agrin and cortactin have been described in patients with myasthenia gravis. To further validate and characterize these autoantibodies, sera and/or plasma exchange material of 135 patients with myasthenia gravis were screened for anti-agrin or anti-cortactin autoantibodies. Autoantibodies against cortactin were detected in three patients and two controls and could be confirmed by cell-based assays using cortactin-transfected human embryonic kidney cells in both controls and one patient, but were not detectable in follow-up sera of the three patients. We did not detect any autoantibodies against agrin. The clinical phenotype of anti-cortactin-positive patients varied, arguing against a relevant pathogenic role.
PMID:33962172 | DOI:10.1016/j.jneuroim.2021.577588
Source: https://pubmed.ncbi.nlm.nih.gov/3396217 ... 3&v=2.14.4