[SMLE] Two Lambert-Eaton Myasthenic Syndrome Patients with Ameliorated Activities of Daily Living Due to Cholinesterase

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Intern Med. 2021 Sep 18. doi: 10.2169/internalmedicine.7902-21. Online ahead of print.

ABSTRACT

We herein report two P/Q-type VGCC antibody-positive LEMS patients who responded dramatically to cholinesterase inhibitors. Patient 1, a 76-year-old man, had small-cell lung cancer and developed LEMS during chemotherapy. When symptomatic treatment was started with pyridostigmine, gait disturbance was ameliorated, and his modified Rankin scale decreased from 4 points to 3 points. Patient 2, a 68-year-old man, had cancer-free LEMS. Distigmine bromide was very effective and ameliorated not only his gait disturbance but also autonomic symptoms, and his modified Rankin scale decreased from 2 points to 1 point. Cholinesterase inhibitors alone may be effective in a small portion of LEMS patients.

PMID:34544947 | DOI:10.2169/internalmedicine.7902-21


Source: https://pubmed.ncbi.nlm.nih.gov/3454494 ... 5&v=2.17.5