[SMLE] Pulmonary Large Cell Neuroendocrine Carcinoma Associated With Lambert-Eaton Syndrome

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Clin Pathol. 2021 Oct 11;14:2632010X211051741. doi: 10.1177/2632010X211051741. eCollection 2021 Jan-Dec.

ABSTRACT

Lambert-Eaton syndrome is a rare paraneoplastic disorder of the neuromuscular junction, characterized by impaired release of acetylcholine, which causes proximal muscle weakness, depressed tendon reflexes, and autonomic changes. Most cases of Lambert-Eaton syndrome present in small-cell lung carcinoma, and only a few cases have been reported in other lung subtypes. Herein, we report a case of 69 years old male patient with Lambert-Eaton syndrome as a rare association with a pulmonary large-cell neuroendocrine carcinoma, which presented 5 months before neoplasm diagnosis. A lobectomy was auspiciously performed. A review of the literature is also presented.

PMID:34661104 | PMC:PMC8512258 | DOI:10.1177/2632010X211051741


Source: https://pubmed.ncbi.nlm.nih.gov/3466110 ... 5&v=2.17.5