[SMLE] Anesthesia For Patients With Myasthenia Gravis
Posté : 01 janv. 2022 12:00
2021 Oct 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–.
ABSTRACT
Neuromuscular (NM) diseases are a common cause of morbidity and mortality. Myasthenia gravis (MG) is one such disease characterized by skeletal muscle weakness and fatigability. In essence, MG is an autoimmune disorder that results from the destruction of post-synaptic nicotinic acetylcholine (ACh) receptors located at the neuromuscular junction (NMJ).
Classically, patients will display increased weakness at the end of the day, or after exercise or exertion, with a resolution of symptoms occurring after rest. Deep tendon reflexes are normal, and autonomic dysfunction is rare. Respiratory muscles often become of significant concern as the disease progresses. The significant effect the disease exerts on the body, as well as the medications often used to treat the disease, yield unique challenges to the anesthesia provider. One must take care throughout the perioperative period to provide the safest care for the patient. Please note, Lambert-Eaton and other myasthenic syndromes, as well as other neuromuscular disorders, will not be covered in depth here.
PMID:34283457 | Bookshelf:NBK572091
Source: https://pubmed.ncbi.nlm.nih.gov/3428345 ... 5&v=2.17.5