[SMLE] Lambert-Eaton myasthenic syndrome in a young girl
Posté : 01 mars 2022 12:00
BMJ Case Rep. 2022 Feb 28;15(2):e245773. doi: 10.1136/bcr-2021-245773.
ABSTRACT
Lambert-Eaton Myasthenic Syndrome (LEMS) is a neuromuscular junction defect that results in weakness. It is rarely seen in children and most commonly is associated with small-cell lung cancer. Diagnosis of LEMS requires characteristic electromyogram (EMG) findings and the detection of antibodies directed against voltage-gated calcium channels. We report the case of an 8-year-old female child who presented with profound weakness found to have EMG evidence of a neuromuscular junction defect and detectable antivoltage-gated calcium channel antibodies. She received plasma exchange electrophoresis, intravenous immunoglobulin, oral steroids and amifampridine with some clinical improvement. We present a case of a child with a demonstrated autoimmune propensity and no evidence of malignancy, thereby adding to the 12 previously reported cases of LEMS in children.
PMID:35228217 | DOI:10.1136/bcr-2021-245773
Source: https://pubmed.ncbi.nlm.nih.gov/3522821 ... 2&v=2.17.5