Myasthenie.com

J Neurosci Rural Pract. 2022 Mar 9;13(2):321-325. doi: 10.1055/s-0042-1743444. eCollection 2022 Apr.

ABSTRACT

Objectives This article describes the clinical outcomes after thymectomy in patients with thymomatous myasthenia gravis (T-MG) managed in the department of thoracic surgery of Hassan II University Hospital of Fez, Fez, Morocco. Materials and Methods We performed a retrospective analysis of medical records of 16 patients with T-MG between January 2009 and January 2017. Results There were 11 women and 5 men with a median age of 40 years at the thymectomy time and a median time of onset of symptoms to thymectomy of 12 months. At the preoperative evaluation (Myasthenia Gravis Foundation of America [MGFA] clinical classification), 7 patients were class II, 7 class III, and 2 class IV. Nine patients were in Masaoka stage I, and the remaining 7 patients stage II. We recorded one case of postoperative myasthenic crisis. At 3 years of follow-up after thymectomy, 6 patients had complete stable remission and the other 10 patients improved. Of these patients with clinical improvement, 6 patients were in MGFA class I and the remaining 4 patients class II. Conclusion The present study shows the beneficial effect of thymectomy in patients with T-MG. Postoperative clinical outcomes seem to be better when the preoperative severity of myasthenic symptoms is mild (MGFA class II).

PMID:35694069 | PMC:PMC9187376 | DOI:10.1055/s-0042-1743444


Source: https://pubmed.ncbi.nlm.nih.gov/3569406 ... 9&v=2.17.6