[Pubmed] Long-Term Remission With Low-Dose Rituximab in Myasthenia Gravis: A Retrospective Study
Posté : 25 août 2022 12:00
J Clin Neuromuscul Dis. 2022 Sep 1;24(1):18-25. doi: 10.1097/CND.0000000000000420.
ABSTRACT
OBJETIVE: Rituximab (RTX) is a therapeutic option, for patients with myasthenia gravis (MG) not responding to conventional immunosuppressive treatment. In this cohort, we evaluated long-term efficacy of RTX in the treatment of refractory generalized MG.
METHODS: A retrospective study was performed in adult patients with refractory generalized MG and at least 24 months of follow-up, between January/2015 and October/2021. The Myasthenia Gravis Status and Treatment Intensity Score was used to assess outcomes, and CD19/CD20+ B-cell counts were monitored.
RESULTS: Sixteen patients with MG (8 antiacetylcholine receptor+ and 8 muscle-specific antikinase+; mean age 45.5 ± 16.2 years) treated with low-dose RTX protocols were included. CD19/CD20 levels remained undetectable 12 months after induction, and no new relapses were observed during follow-up.
CONCLUSIONS: Low-dose RTX infusions were sufficient to achieve undetectable CD19/20 cell counts and sustained clinical remission. In low and middle-income countries, the impact of low-dose RTX therapy represents a paradigm shift in decision-making for long-term treatment.
PMID:36005470 | DOI:10.1097/CND.0000000000000420
Source: https://pubmed.ncbi.nlm.nih.gov/3600547 ... 5&v=2.17.7