[Pubmed] D-penicillamine Induced Myasthenia Gravis in Wilson's Disease: A Case Report
Posté : 27 janv. 2023 12:00
JNMA J Nepal Med Assoc. 2022 Jul 1;60(251):644-647. doi: 10.31729/jnma.7607.
ABSTRACT
Myasthenia gravis is a neuromuscular junction disorder characterised by fluctuating muscle weakness, improved by using anti-cholinesterase drugs. In addition to the autoimmune aetiology, various factors such as infections, surgery, and drugs are known to precipitate the condition. We report a case of a 15-year-old boy with D-penicillamine-induced myasthenia gravis who presented with facial diplegia, dysphagia, and drooling of saliva, 6 years after the initiation of treatment for Wilson's disease. Therefore, clinicians should be more vigilant while prescribing patients with chelating drugs like D-penicillamine with regular monitoring of the new symptoms and keeping a very low threshold for the suspicion of myasthenia gravis.
KEYWORDS: d-penicillamine; myasthenia gravis; pyridostigmine; Wilson's disease.
PMID:36705187 | DOI:10.31729/jnma.7607
Source: https://pubmed.ncbi.nlm.nih.gov/3670518 ... t6+86293ac