[SMLE] Cancer detection after a 9-year course of Lambert-Eaton myasthenic syndrome complicated by anti-Hu associated lim

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Neuromuscul Disord. 2023 Jun 30:S0960-8966(23)00168-2. doi: 10.1016/j.nmd.2023.06.011. Online ahead of print.

ABSTRACT

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune neuromuscular junction disorder, paraneoplastic in 55% of cases and commonly associated with small-cell lung cancer (SCLC). We report the case of a 61-year-old man presented who with a 3-month history of lower limb proximal weakness, progressing to upper limbs, associated with dysphagia, xerostomia and erectile dysfunction. Electrodiagnostic studies and anti voltage-gated calcium channel (VGCC) antibodies (Abs) detection confirmed LEMS diagnosis. Contrast-enhanced thorax computed tomography (CT) scan and subsequently [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) showed no malignancy. Two years after the onset of LEMS, he was diagnosed with anti-Hu limbic encephalitis (LE). FDG-PET/CT scan remained negative for the following seven years. Nine years after LEMS onset, a hypermetabolic lesion of the left lung hilus was detected. This is a case of a paraneoplastic LEMS where the interval between the onset of neurological disease and tumour detection was as long as nine years.

PMID:37507235 | DOI:10.1016/j.nmd.2023.06.011


Source: https://pubmed.ncbi.nlm.nih.gov/3750723 ... t6+86293ac