[Pubmed] Serum cytokine profiles in myasthenia gravis with anti-muscle-specific kinase antibodies
Posté : 29 sept. 2023 12:00
J Neuroimmunol. 2023 Sep 20;384:578205. doi: 10.1016/j.jneuroim.2023.578205. Online ahead of print.
ABSTRACT
This study measured the serum levels of of 15 cytokines in 15 patients with anti-muscle-specific kinase antibody-positive MG (MuSK-MG) using a multiplex suspension array system. Fifteen patients with non-inflammatory neurological diseases served as controls. Compared with controls, patients with MuSK-MG showed higher levels of Th1- (IFN-γ), Th2- (IL-25, IL-31, and IL-33), Th17- (IL-22), Treg-related cytokines (IL-10), and soluble CD40 ligand (sCD40L). Higher serum Th2-related cytokines (IL-25 and IL-31) levels were correlated with less MG Foundation of America (MGFA) class. These suggest that Th2-related cytokines have protective effects, whereas sCD40L and others may facilitate the disease.
PMID:37774555 | DOI:10.1016/j.jneuroim.2023.578205
Source: https://pubmed.ncbi.nlm.nih.gov/3777455 ... t6+86293ac