[Pubmed] Study of serum exosome miRNA as a biomarker for early onset adult ouclar myasthenia gravis
Posté : 28 nov. 2023 12:00
Gene. 2023 Nov 25:148034. doi: 10.1016/j.gene.2023.148034. Online ahead of print.
ABSTRACT
BACKGROUND: By extracting and sequencing miRNAs from serum exosomes of patients with early-onset ocular myasthenia gravis (OMG), generalized myasthenia gravis (GMG) and healthy controls, we screened differentially expressed miRNAs and explored the possibility as potential biomarkers for early-onset OMG.
METHODS: Peripheral blood samples were collected from patients with early-onset OMG, early-onset GMG, and age-matched healthy subjects, with 6 samples in each group. All these patients were diagnosed as MG for the first time and did not undergo any treatment. Exosomes miRNAs were extracted from the serum and performed deep sequencing; the differentially expressed miRNAs were compared and analyzed between OMG, GMG, and healthy control groups using edgeR. The differential expression standard was set to | log2FC |>1, p
Source: https://pubmed.ncbi.nlm.nih.gov/3801312 ... t6+86293ac