[Pubmed] Autoimmune thyroid disease and myasthenia gravis: a study bidirectional Mendelian randomization
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Auteur du sujet - Ami(e) de Diamant
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[Pubmed] Autoimmune thyroid disease and myasthenia gravis: a study bidirectional Mendelian randomization
Front Endocrinol (Lausanne). 2024 Feb 9;15:1310083. doi: 10.3389/fendo.2024.1310083. eCollection 2024.
ABSTRACT
BACKGROUND: Previous studies have suggested a potential association between AITD and MG, but the evidence is limited and controversial, and the exact causal relationship remains uncertain.
OBJECTIVE: Therefore, we employed a Mendelian randomization (MR) analysis to investigate the causal relationship between AITD and MG.
METHODS: To explore the interplay between AITD and MG, We conducted MR studies utilizing GWAS-based summary statistics in the European ancestry. Several techniques were used to ensure the stability of the causal effect, such as random-effect inverse variance weighted, weighted median, MR-Egger regression, and MR-PRESSO. Heterogeneity was evaluated by calculating Cochran's Q value. Moreover, the presence of horizontal pleiotropy was investigated through MR-Egger regression and MR-PRESSO.
RESULTS: The IVW method indicates a causal relationship between both GD(OR 1.31,95%CI 1.08 to 1.60,P=0.005) and autoimmune hypothyroidism (OR: 1.26, 95% CI: 1.08 to 1.47, P =0.002) with MG. However, there is no association found between FT4(OR 0.88,95%CI 0.65 to 1.18,P=0.406), TPOAb(OR: 1.34, 95% CI: 0.86 to 2.07, P =0.186), TSH(OR: 0.97, 95% CI: 0.77 to 1.23, P =0.846), and MG. The reverse MR analysis reveals a causal relationship between MG and GD(OR: 1.50, 95% CI: 1.14 to 1.98, P =3.57e-3), with stable results. On the other hand, there is a significant association with autoimmune hypothyroidism(OR: 1.29, 95% CI: 1.04 to 1.59, P =0.019), but it is considered unstable due to the influence of horizontal pleiotropy (MR PRESSO Distortion Test P < 0.001). MG has a higher prevalence of TPOAb(OR: 1.84, 95% CI: 1.39 to 2.42, P =1.47e-5) positivity and may be linked to elevated TSH levels(Beta:0.08,95% CI:0.01 to 0.14,P =0.011), while there is no correlation between MG and FT4(Beta:-9.03e-3,95% CI:-0.07 to 0.05,P =0.796).
CONCLUSION: AITD patients are more susceptible to developing MG, and MG patients also have a higher incidence of GD.
PMID:38405140 | PMC:PMC10884276 | DOI:10.3389/fendo.2024.1310083
Source: https://pubmed.ncbi.nlm.nih.gov/3840514 ... t9+e462414
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Pour obtenir la traduction en français,
cliquez sur le bouton situé dans la barre des menus en haut de cette page
Pour les donateurs, si cet article vous intéresse, nous pouvons faire l’acquisition d'un tiré-à-part.
Merci d'en faire la demande sur association.amis-modo@myasthenie.com
Bonne lecture...