[Pubmed] Anti-titin antibodies in a cohort of myasthenia gravis patients
Posté : 20 mars 2024 11:00
J Thorac Dis. 2024 Feb 29;16(2):973-978. doi: 10.21037/jtd-23-94. Epub 2024 Feb 26.
ABSTRACT
BACKGROUND: Anti-titin antibodies have been previously associated with thymoma-associated myasthenia gravis (MG) and a more clinically severe form of MG. While currently only serving as a disease biomarker, its possible utility as an indicator of underlying thymus malignancy may be of value in clinical practice.
METHODS: Data was retrospectively collected and analyzed from 2013 to 2022 using an institutional record of MG patients. Anti-titin antibodies were assessed using Line Blot immunoassay.
RESULTS: From 130 MG cases, 32 (24.6%) were anti-titin positive. Anti-titin positive cases were associated with older age of disease onset [median (IQR): 63.0 (44.3-70.8) vs. 35.5 (24.8-60.8) years] (P
Source: https://pubmed.ncbi.nlm.nih.gov/3850507 ... t9+e462414