[pubmed] Transient neonatal myasthenia gravis: refining risk estimate for infants born to women with myasthenia gravis

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J Perinatol. 2021 Feb 17. doi: 10.1038/s41372-021-00970-6. Online ahead of print.

ABSTRACT

OBJECTIVE: Transient neonatal myasthenia gravis (TNMG) can render a neonate vulnerable to catastrophic respiratory depression. Our aim was to describe the clinical manifestations of TNMG, and to determine when the myasthenic signs become apparent in TNMG.

METHODS: We reviewed our own experience of infants who underwent routine inpatient monitoring for TNMG and combined our local data with observations from previous studies.

RESULTS: Only three case series (n = 110) reported both the type and timing of onset of myasthenic signs. Adding local data (n = 37) yielded 147 infants born to women with MG. Fifteen infants (10%) developed signs of TNMG with onset being 1.5 ± 2.6 days (mean ± 3SD) after birth. Feeding difficulties and low tone were the commonest presenting signs, and only 1 of the 147 infants needed intubation for hypoventilation.

CONCLUSIONS: TNMG signs were mostly not life-threatening. We suggest only 4 days of routine postnatal observation for infants born to women with MG.

PMID:33597740 | DOI:10.1038/s41372-021-00970-6


Source: https://pubmed.ncbi.nlm.nih.gov/3359774 ... 0&v=2.14.2