[pubmed] The role of innate immunity in myasthenia gravis

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Autoimmun Rev. 2021 Mar 12:102800. doi: 10.1016/j.autrev.2021.102800. Online ahead of print.

ABSTRACT

Myasthenia gravis (MG) is a T cell-driven, B cell-mediated and autoantibody-dependent autoimmune disorder against neuromuscular junctions (NMJ). Accumulated evidence has emerged regarding the role of innate immunity in the pathogenesis of MG. In this review, we proposed two hypothesis underlying the pathological mechanism. In the context of gene predisposition, on the one hand, Toll-like receptors (TLRs) pathways were initiated by viral infection in the thymus with MG to generate chemokines and pro-inflammatory cytokines such as Type I interferon (IFN), which facilitate the thymus to function as a tertiary lymphoid organ (TLO). On the another hand, the antibodies against acetylcholine receptors (AChR) generated by thymus then activated the classical pathways on thymus and neuromuscular junction (NMJ). Futher, we also highlight the role of innate immune cells in the pathogenic response. Finally, we provide some future perspectives in developing new therapeutic approaches particularly targeting the innate immunity for MG.

PMID:33722749 | DOI:10.1016/j.autrev.2021.102800


Source: https://pubmed.ncbi.nlm.nih.gov/3372274 ... 0&v=2.14.3