[pubmed] A rare case of nivolumab-related myasthenia gravis and myocarditis in a patient with metastatic gastric cancer

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BMC Gastroenterol. 2021 Aug 26;21(1):333. doi: 10.1186/s12876-021-01904-4.

ABSTRACT

BACKGROUND: Although rare, several immune-related adverse effects can be life-threatening. Here, we describe a metastatic gastric cancer patient presenting with nivolumab-related myasthenia gravis and myocarditis, a previously unreported adverse effect of gastric cancer treatment.

CASE PRESENTATION: A 66-year-old man with metastatic gastric cancer visited the emergency department because of dizziness after the first dose of nivolumab. Diagnoses of nivolumab-related myasthenia gravis and myocarditis were established. Myocardial biopsy results and anti-acetylcholine receptor antibody positivity confirmed the diagnoses. Despite plasma exchange and intravenous methylprednisolone and immunoglobulin administration, the patient's general condition gradually worsened, and he died.

CONCLUSIONS: Strict monitoring for cardiac and neuromuscular symptoms after nivolumab administration is necessary to rapidly treat these adverse effects.

PMID:34445963 | DOI:10.1186/s12876-021-01904-4


Source: https://pubmed.ncbi.nlm.nih.gov/3444596 ... 5&v=2.14.5