[Pubmed] Transient Neonatal Myasthenia Gravis: A Case Report

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Cureus. 2021 Dec 22;13(12):e20592. doi: 10.7759/cureus.20592. eCollection 2021 Dec.

ABSTRACT

Myasthenia gravis (MG) in the neonate is usually due to placentally transferred antibodies to the acetylcholine receptor (AChR), resulting in impaired neuromuscular transmission. It occurs in 10%-15% of newborns born to women with MG. We present a male newborn admitted to the neonatal intensive care unit (NICU) 38 hours after birth due to feeding difficulties and choking episodes. He was born to a mother with MG after an uneventful, well-followed pregnancy. Physical examination revealed a weak cry, persistent inability to fully close his eyelids, weak facial mimic, and a mouth that was always held open with swallowing and sucking difficulties. He assumed a frog leg position and showed generalized hypotonia with marked head lag. No respiratory distress was present. Laboratory evaluation showed an elevated anti-acetylcholine receptor antibody concentration (36.30 nmol/L; normal:

Source: https://pubmed.ncbi.nlm.nih.gov/3510316 ... 7&v=2.17.5