[Pubmed] Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium C

[RSS-Bot]

Intern Med. 2022 Mar 19. doi: 10.2169/internalmedicine.8772-21. Online ahead of print.

ABSTRACT

Immune checkpoint inhibitors (ICIs) are complicated by immune-related adverse events (irAEs), such as myositis, myocarditis, and myasthenia gravis (MG). Anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody are anti-striated antibodies that are frequently detected in MG patients with myositis and/or myocarditis. However, the clinical relationship between positive anti-striated antibodies and irAEs of ICIs remains unknown. We herein report a case of nivolumab-induced myositis and myocarditis with positive anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody in a patient with non-small-cell lung cancer. We also review reported cases of positive anti-striated antibodies related to irAEs of ICIs.

PMID:35314545 | DOI:10.2169/internalmedicine.8772-21


Source: https://pubmed.ncbi.nlm.nih.gov/3531454 ... 5&v=2.17.6