[Pubmed] Observation on the efficacy of different methylprednisolone regimens in the treatment of myasthenia gravis

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Pak J Med Sci. 2022 Mar-Apr;38(4Part-II):910-915. doi: 10.12669/pjms.38.4.5069.

ABSTRACT

OBJECTIVE: To investigate the efficacy of different methylprednisolone regimens in the treatment of myasthenia gravis (MG).

METHODS: A total of 98 patients with MG admitted to Shijiazhuang People's Hospital from December 2018 to November 2019 were randomly divided into two groups, with 49 cases in each group. Patients in the control group received high-dose methylprednisolone pulse therapy, while those in the experimental group received medium-dose periodic therapy of methylprednisolone. Anti-acetylcholine receptor antibodies (AChRab), clinical absolute scores, complement levels (C3, C4), T lymphocyte subsets (CD3+, CD4+, CD4+CD25+), cytokines [interferon-γ (INF-γ), transforming growth factor-β1 (TGF-β1), interleukin-6 (IL- 6), interleukin-18 (IL-18)], and changes in quality of life [15-item Myasthenia Gravis Quality of Life Scale (MGQOL-15) score] were compared between the two groups before treatment and one and three months after treatment. Moreover, the incidence of adverse drug reactions in the two groups during 3 months of treatment was compared.

RESULTS: After three months of treatment, ACHRAB, clinical absolute score, CD3+, CD4+, INF-γ, IL-6, IL-18 and MGQOL-15 scores in both groups were significantly decreased compared with those before treatment (p

Source: https://pubmed.ncbi.nlm.nih.gov/3563461 ... 7&v=2.17.6