[Pubmed] SARS-CoV-2 vaccination and new-onset myasthenia gravis: A report of 7 cases and review of the literature

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Neuromuscul Disord. 2022 Sep 5:S0960-8966(22)00650-2. doi: 10.1016/j.nmd.2022.09.001. Online ahead of print.

ABSTRACT

Myasthenia gravis (MG) is an antibody-mediated immune disorder of the neuromuscular junction. SARS-CoV-2 is now recognised as a trigger factor for autoimmune diseases and to cause immune-mediated dysregulation, likely due to molecular mimicry induced by viral antigens. SARS-CoV-2 vaccination, similarly, results in exposure to viral antigen. Here we report 7 cases of new-onset myasthenia gravis in timely association with SARS-CoV-2 vaccination, including the first paediatric case identified to date. We also reviewed the literature for other new-onset MG cases reported within 4 weeks of SARS-CoV-2 vaccination and discuss our findings in the context of altered (auto)immunity following SARS-CoV-2 vaccination and/or infection.

PMID:36130855 | DOI:10.1016/j.nmd.2022.09.001


Source: https://pubmed.ncbi.nlm.nih.gov/3613085 ... 7&v=2.17.8