[Pubmed] A comprehensive review on the importance of miRNA-206 in animal model and human diseases

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Curr Neuropharmacol. 2023 Apr 7. doi: 10.2174/1570159X21666230407124146. Online ahead of print.

ABSTRACT

MicroRNA-206 (miR-206) is a microRNA which is involved in many human diseases, such as myasthenia gravis, osteoarthritis, depression, cancers and so on. Both inhibition effects and expansionary roles of miR-206 have been reported for the past few years. High expression of miR-206 was observed in patients with osteoarthritis, gastric cancer and epithelial ovarian cancer as compared with normal people. The study also showed that miR-206 promotes cancer progression in breast cancer patients and avascular necrosis of femoral head. And meanwhile, there are several studies that have shown that expression levels of miR-206 were down- regulated in laryngeal carcinoma cell multiplication, as well as in the hepatocellular carcinoma, non-small lung cancer and infantile hemangioma. And interestingly enough, miR-206 was up-regulated in the mild stage of amyotrophic lateral sclerosis patients, then down-regulated in the moderate and severe stages, it shows miR-206 has the double effects of starting and aggravating the disease. In neuropsychiatric disorders such as depression, miR-206 also plays an important role in the progression of the disease, the level of miR-206 is most highly expressed in the brains of patients with depression. In the current review, we summarize the role of miR-206 in various diseases, and miR-206 may be developed as new biomarkers for diagnosing diseases in the near future.

PMID:37032500 | DOI:10.2174/1570159X21666230407124146


Source: https://pubmed.ncbi.nlm.nih.gov/3703250 ... t6+86293ac