[Pubmed] Myasthenia gravis with inclusion body myositis: A case report

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Mod Rheumatol Case Rep. 2023 May 20:rxad026. doi: 10.1093/mrcr/rxad026. Online ahead of print.

ABSTRACT

We present the case of a 75-year-old man diagnosed with myasthenia gravis (MG) based on lower-leg weakness and ptosis for two months before admission to our hospital. The patient was anti-acetylcholine receptor antibody-positive at admission. He was treated with pyridostigmine bromide and prednisolone, which improved the ptosis, but the lower-leg muscle weakness remained. An additional lower-leg magnetic resonance imaging exam suggested myositis. Inclusion body myositis (IBM) was diagnosed after a subsequent muscle biopsy. Although MG is often associated with inflammatory myopathy, IBM is rare. There is no effective treatment for IBM, but various treatment possibilities have recently been proposed. This case emphasises that myositis complications, including IBM, should be considered when elevated creatine kinase levels are observed and conventional treatments do not address chronic muscle weakness.

PMID:37210209 | DOI:10.1093/mrcr/rxad026


Source: https://pubmed.ncbi.nlm.nih.gov/3721020 ... t6+86293ac