[Pubmed] Effect of thymectomy on the frequencies of peripheral regulatory B and T lymphocytes in patients with Myastheni

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Int J Neurosci. 2023 Sep 5:1-17. doi: 10.1080/00207454.2023.2254922. Online ahead of print.

ABSTRACT

AIM: We aimed to investigate the relationship between the peripheral lymphocyte subset frequency and thymectomy in patients with myasthenia gravis (MG).

MATERIALS AND METHODS: The frequencies of regulatory B (Breg) and regulatory T (Treg) cells in peripheral blood samples obtained from 69 patients with MG and 10 healthy controls were analyzed using flow cytometry. Serum acetylcholine receptor antibodies (AchR-Ab) were measured. Patients with MG were subdivided into pre-thymectomy, post-thymectomy, and normal thymus control group.

RESULTS: The percentage of Breg cells was significantly decreased in both the pre-thymectomy (7.92 ± 1.30%) and post-thymectomy (8.14 ± 1.34%) groups compared to healthy controls (16.02 ± 2.78%) and reduced in the acute phase compared to stable maintenance. The proportion of cluster of differentiation (CD) 4 + CD25 + T cells and CD4 + CD25 + CD127low/- Treg cells in MG patients were not significantly different than healthy controls. AchR-Ab titers in aggravating or recurrence patients after thymectomy were significantly higher than that of the stable remission patients (11.13 ± 0.70 and 6.03 ± 0.85 nmol/L, respectively; P < 0.001).

CONCLUSION: The frequency of Breg cells may serve as a potential indicator of MG prognosis, while Treg cell frequency did not demonstrate the same prognostic ability. The concentration of AchR-Ab can be used as a dynamic monitoring index of disease severity in patients with MG.

PMID:37668142 | DOI:10.1080/00207454.2023.2254922


Source: https://pubmed.ncbi.nlm.nih.gov/3766814 ... t6+86293ac