[Pubmed] Efgartigimod Successfully Ameliorated Acute Exacerbation of Myasthenia Gravis with Anti-muscle-specific Kinase

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Intern Med. 2024 Aug 8. doi: 10.2169/internalmedicine.3726-24. Online ahead of print.

ABSTRACT

We herein report two patients with anti-muscle-specific kinase (MuSK) antibody-positive myasthenia gravis who experienced rapid deterioration of weakness, particularly respiratory muscle weakness, necessitating non-invasive positive pressure ventilation (NIPPV) and were treated with efgartigimod. After treatment initiation, a rapid reduction in IgG levels and recovery from clinical symptoms were observed. NIPPV was no longer required two to three weeks after the first infusion of efgartigimod. These findings suggest that the reduction of IgG levels using efgartigimod is a good treatment option in patients with myasthenia gravis positive for anti-MuSK antibodies, even during the acute phase of the disease.

PMID:39111891 | DOI:10.2169/internalmedicine.3726-24


Source: https://pubmed.ncbi.nlm.nih.gov/3911189 ... t9+e462414