[Pubmed] Myasthenia gravis complicated by Graves' disease: a case report

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J Med Case Rep. 2025 Jul 29;19(1):375. doi: 10.1186/s13256-025-05198-y.

ABSTRACT

INTRODUCTION: Myasthenia gravis is a neuromuscular autoimmune condition characterized by the presence of antibodies against acetylcholine receptors. It may present as a generalized disorder or remain limited to specific muscle groups. Myasthenia gravis can occur independently or alongside other autoimmune conditions, including Hashimoto's thyroiditis and Graves' disease. Although the co-occurrence of these disorders is recognized, it is an extremely rare clinical phenomenon.

CASE PRESENTATION: A 20-year-old woman of Muganda ethnicity, with a 2-year history of Graves' disease confirmed by thyroid scintigraphy, developed a myasthenic syndrome leading to acute respiratory failure. Her condition improved with the administration of Prostigmine. Further investigations, including electrophysiological studies and immunological tests, confirmed a diagnosis of myasthenia gravis. The patient demonstrated a positive response to medical therapy.

CONCLUSION: This case highlights the importance of recognizing the rare association between myasthenia gravis and Graves' disease. Accurate diagnosis and effective treatment require a coordinated, multidisciplinary approach, particularly given the challenges posed by overlapping symptoms and the exacerbating effects of hyperthyroidism on myasthenia gravis.

PMID:40734191 | DOI:10.1186/s13256-025-05198-y


Source: https://pubmed.ncbi.nlm.nih.gov/4073419 ... t9+e462414