[Pubmed] Outcomes in Relation to the Age at Onset in Patients With Myasthenia Gravis

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Neurology. 2025 Dec 23;105(12):e214428. doi: 10.1212/WNL.0000000000214428. Epub 2025 Nov 20.

ABSTRACT

BACKGROUND AND OBJECTIVES: Patients with myasthenia gravis (MG) exhibit significant heterogeneity based on age at disease onset. However, existing retrospective studies in China remain confined to single-center settings with limitations in sample size adequacy. The aim of this study was to compare clinical characteristics, treatment responsiveness, and long-term postintervention status of patients with MG across different onset ages.

METHODS: This was an observational, cross-sectional, multicenter, retrospective study. We reviewed the medical records of patients diagnosed with MG who were hospitalized in 3 MG centers of China from January 2012 to December 2022. Demographic information, clinical characteristics, and therapeutic data were extracted from the electronic medical record system, and responsiveness to treatment was followed up. Patients were classified into 3 age subgroups: juvenile MG (age at onset

Source: https://pubmed.ncbi.nlm.nih.gov/4126489 ... 22+67771e2