[Pubmed] Long-term outcomes of anti-CD19 CAR T cell therapy in refractory myasthenia gravis: A case series

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Cell Rep Med. 2026 Aug 21:103000. doi: 10.1016/j.xcrm.2026.103000. Online ahead of print.

ABSTRACT

Anti-CD19 CAR T cell therapy represents an emerging therapeutic approach for generalized, treatment-refractory myasthenia gravis (MG), a predominantly B-cell-mediated autoimmune disease for which durable treatment-free remission remains an unmet clinical goal. Despite recent advances, current targeted therapies generally require lifelong repeated administration and rarely induce durable treatment-free remission. We report on three patients with severe, treatment-resistant MG, including one patient with concomitant rheumatoid arthritis, treated with autologous, fully human anti-CD19 CAR T cells. All three patients achieve rapid, sustained clinical MG remission for at least 19 months, allowing discontinuation of MG-specific immunotherapies and substantial improvement in clinical and functional outcomes despite persistent detectable anti-AChR autoantibody titers. B cell depletion is profound, and treatment-related adverse events remain transient and manageable during long-term follow-up. These data support anti-CD19 CAR T cell therapy as a durable, effective intervention for refractory MG and warrant further evaluation in prospective controlled clinical trials.

PMID:42628528 | DOI:10.1016/j.xcrm.2026.103000


Source: https://pubmed.ncbi.nlm.nih.gov/4262852 ... 6&v=2.20.1