[Pubmed] Association Between Pleural Breach and Perioperative and Long-Term Outcomes after Thymectomy for Myasthenia Gra

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Thorac Res Pract. 2026 Oct 9. doi: 10.4274/ThoracResPract.2026.2026-3-3. Online ahead of print.

ABSTRACT

OBJECTIVE: Thymectomy is an established treatment for myasthenia gravis and thymic tumors. This study evaluated the impact of pleural breach on perioperative pleural-related morbidity and long-term neurologic and oncologic outcomes following thymectomy.

MATERIAL AND METHODS: A retrospective multicenter review of 455 patients who underwent thymectomy between January 2005 and December 2024 was conducted at Services Hospital and Surgimed Hospital, Lahore, Pakistan. Patients underwent either a partial transsternal thymectomy (n = 273) or a video-assisted thoracoscopic surgery (VATS) thymectomy (n = 182). The primary outcome was pleural-related postoperative morbidity. Secondary outcomes included neurologic remission, recurrence-free survival (RFS), postoperative complications, and hospital stay.

RESULTS: Pleural breach occurred in all VATS cases and incidentally in 29 (10.6%) transsternal cases. VATS thymectomy was associated with lower blood loss (P < 0.001) and shorter hospital stay (P < 0.001), but with longer operative time (P < 0.001). Pleural-related complications were more frequent following pleural breach, but were generally transient and were managed conservatively. On multivariable analysis, pleural breach independently predicted pleural-related morbidity [odds ratio (OR): 2.6, P = 0.006]. The combined proportion of patients achieving complete stable remission, pharmacologic remission, or clinical improvement exceeded 90%. Neurologic remission and 5-year RFS were comparable between groups (P = 0.612 and P = 0.538, respectively).

CONCLUSION: Pleural breach during thymectomy was independently associated with increased transient pleural-related postoperative morbidity (OR: 2.6). However, these complications were generally self-limited and managed conservatively. Long-term neurologic remission and RFS were comparable between surgical approaches, but these findings should be interpreted cautiously given the retrospective observational design.

PMID:42853014 | DOI:10.4274/ThoracResPract.2026.2026-3-3


Source: https://pubmed.ncbi.nlm.nih.gov/4285301 ... 3&v=2.20.1