Lu sur : https://www.ncbi.nlm.nih.gov/pubmed/32329050
Prévalence et risque de maladies thyroïdiennes dans la myasthénie grave.
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Titre de l'article Prevalence and risk of thyroid diseases in myasthenia gravis.
Date de l'article Acta Neurol Scand. 2020 Apr 23. doi: 10.1111/ane.13254. [Epub ahead of print]
Contenu de l'article
Objectives:
To estimate the prevalence of thyroid diseases and the cumulative risk of thyroid diseases during a follow-up period after myasthenia gravis diagnosis (MG) compared with non-MG control groups.
MATERIALS & METHODS:
We used the Taiwan National Health Insurance Database linked to Registry of Catastrophic Illness database to identify patients with MG. The control groups were composed of those who did not have MG and were matched with the MG patients by sex, age and index date. We recorded thyroid disease histories before and after the index date.
RESULTS:
Our study included 5,813 MG patients and 29,025 control groups. The prevalence of thyroid diseases in the MG patients at diagnosis was 18.4%, which was nearly 3.9-fold greater than that in the control groups. (Odds ratio [OR] 3.89, 95% Confidence interval [CI] 3.574-4.246) After excluding pre-existing thyroid diseases, the incidence of comorbid thyroid diseases was 8.7% in the MG patients and 4% in the control groups. The MG patients had a 2.36-fold increased risk of developing thyroid diseases compared to the control groups. (HR 2.36, 95% CI 2.10-2.66) The cumulative probabilities of developing thyroid diseases at 1,5,10 years after the index date were 21.6%, 24.9%, and 28.7%, respectively, in the MG patients, while the cumulative probabilities were and 6.5%, 8.8%, and 11.8%, respectively, in control groups (log-rank test <.0001).
CONCLUSIONS:
The current population-based study showed a higher prevalence of pre-existing thyroid diseases and a higher cumulative probability of thyroid diseases during follow-up after MG diagnosis than in the general population.
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