[pubmed] A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis

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Int J Mol Sci. 2021 Nov 30;22(23):12964. doi: 10.3390/ijms222312964.

ABSTRACT

Myasthenia gravis (MG) is an autoimmune condition related to autoantibodies against certain proteins in the postsynaptic membranes in the neuromuscular junction. This disorder has a multifactorial inheritance. The connection between environmental and genetic factors can be established by epigenetic factors, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). XLOC_003810, SNHG16, IFNG-AS1, and MALAT-1 are among the lncRNAs with a possible role in the pathoetiology of MG. Moreover, miR-150-5p, miR-155, miR-146a-5p, miR-20b, miR-21-5p, miR-126, let-7a-5p, and let-7f-5p are among miRNAs whose roles in the pathogenesis of MG has been assessed. In the current review, we summarize the impact of miRNAs and lncRNAs in the development or progression of MG.

PMID:34884767 | DOI:10.3390/ijms222312964


Source: https://pubmed.ncbi.nlm.nih.gov/3488476 ... 4&v=2.15.0