[Pubmed] Myasthenia Gravis: An Acquired Interferonopathy?

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Cells. 2022 Apr 4;11(7):1218. doi: 10.3390/cells11071218.

ABSTRACT

Myasthenia gravis (MG) is a rare autoimmune disease mediated by antibodies against components of the neuromuscular junction, particularly the acetylcholine receptor (AChR). The thymus plays a primary role in AChR-MG patients. In early-onset AChR-MG and thymoma-associated MG, an interferon type I (IFN-I) signature is clearly detected in the thymus. The origin of this chronic IFN-I expression in the thymus is not yet defined. IFN-I subtypes are normally produced in response to viral infection. However, genetic diseases called interferonopathies are associated with an aberrant chronic production of IFN-I defined as sterile inflammation. Some systemic autoimmune diseases also share common features with interferonopathies. This review aims to analyze the pathogenic role of IFN-I in these diseases as compared to AChR-MG in order to determine if AChR-MG could be an acquired interferonopathy.

PMID:35406782 | DOI:10.3390/cells11071218


Source: https://pubmed.ncbi.nlm.nih.gov/3540678 ... 9&v=2.17.6