[SMLE] A case of Lambert-Eaton myasthenic syndrome with exacerbation of respiratory failure triggered by acute myocardia

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Rinsho Shinkeigaku. 2023 May 17. doi: 10.5692/clinicalneurol.cn-001849. Online ahead of print.

ABSTRACT

The patient, a 58-year-old man, experienced weakness of the proximal muscles in both lower extremities, and Lambert-Eaton myasthenic syndrome and small cell carcinoma of unknown primary origin were diagnosed. He received symptomatic treatment for myasthenia and radiochemotherapy for small cell carcinoma; once this regimen, the myasthenic symptoms improved. However, acute myocardial infarction occurred, after which type II respiratory failure developed, and the patient required ventilator management with tracheal intubation. Acute-phase treatment, such as plasma exchange, intravenous immune globulin therapy, and methylprednisolone pulse therapy, and intensification of symptomatic treatment allowed for extubation, and eventually the patient was able to walk independently. According to electrophysiological examination, compound muscle action potentials were larger at discharge than at the time of exacerbation.

PMID:37197968 | DOI:10.5692/clinicalneurol.cn-001849


Source: https://pubmed.ncbi.nlm.nih.gov/3719796 ... t6+86293ac