[Pubmed] Myasthenia-like paraneoplastic syndrome with multiple cranial nerve tumor infiltration: A case report and liter

[RSS-Bot]

Medicine (Baltimore). 2023 May 19;102(20):e33774. doi: 10.1097/MD.0000000000033774.

ABSTRACT

RATIONALE: Approximately 0.001% of patients with cancer have paraneoplastic nerve system syndrome, which can affect the central nervous system, neuromuscular junction, or peripheral nervous system. Although myasthenia gravis (MG) may exist as a thymic paraneoplastic syndrome (PNPS), its association with primary lung cancer remains unknown.

PATIENT CONCERNS: A 55-year-old female presented with slurred speech, weakness in chewing, sporadic difficulty in swallowing, and weakness in both lower limbs for half a year.

DIAGNOSES: Based on cerebrospinal fluid and electromyography findings, we present the case of a female patient diagnosed with overlapping multicranial nerve tumor infiltration and MG-like neurological PNPS secondary to lung adenocarcinoma.

INTERVENTIONS: The patient received intrathecal injections of pemetrexed and neurotrophic (vitamin B) therapy before ceasing chemoradiotherapy and chose cabozantinib on her own.

OUTCOMES: Weakness of the proximal limbs, choking cough, and chewing problems did not improve significantly.

LESSONS: Although it is unclear why MG coexists with lung cancer, it is probable that MG is a paraneoplastic condition. Cerebrospinal fluid testing should be carried out along with electrophysiological, serological, and pharmacological procedures pertinent to the diagnosis of MG to thoroughly examine if people simultaneously experience MG-like PNPS and tumor growth. Starting immunotherapy and anticancer medication at the same time that tumor development and MG-like syndrome are discovered is crucial.

PMID:37335736 | DOI:10.1097/MD.0000000000033774


Source: https://pubmed.ncbi.nlm.nih.gov/3733573 ... t6+86293ac