[Pubmed] Pembrolizumab-induced Myasthenia Gravis and Myocarditis

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J Community Hosp Intern Med Perspect. 2024 May 7;14(3):85-88. doi: 10.55729/2000-9666.1352. eCollection 2024.

ABSTRACT

As the use of immune checkpoint inhibitors (ICPi) such as pembrolizumab is rapidly expanding in the field of immuno-oncology, it is crucial for healthcare providers to be aware of their immune-related adverse events (irAE) which are thought to be driven by augmented immune response of T-cells. While neurologic irAE are underrepresented in literature, their consequences could lead to fatal outcomes. In this report, we describe the case of a patient with excellent performance status prior to pembrolizumab therapy who subsequently suffered myasthenic crisis eventually requiring tracheostomy and long-term mechanical ventilation.

PMID:39036582 | PMC:PMC11259487 | DOI:10.55729/2000-9666.1352


Source: https://pubmed.ncbi.nlm.nih.gov/3903658 ... t9+e462414